Чернющий акантоз

dok_zlo — 19.03.2023

Malignant Acanthosis Nigricans.A 30-year-old woman presented to the dermatology clinic with a 3-month history of progressive skin lesions on her face. On physical examination, there were hyperpigmented, yellow, papillomatous papules and plaques on her lips, perioral area, and nasal creases (Panel A). Hyperpigmented velvety plaques were also seen on her neck, inguinal regions, and axillae (Panel B). She also reported new-onset heartburn, fatigue, and an unintentional 15-kg weight loss. Skin biopsy of a facial lesion showed epidermal papillomatosis, acanthosis, hyperkeratosis, and negative staining for human papillomavirus. A diagnosis of malignant acanthosis nigricans was suspected. Malignant acanthosis nigricans is a paraneoplastic dermopathy involving the sudden onset of velvety plaques on cutaneous and mucosal surfaces. The skin changes are more extensive and rapidly worsening than those in benign acanthosis nigricans. Computed tomography of the abdomen and pelvis showed thickening of the gastric body (Panel C, asterisks) and a solid mass measuring 4.4 cm in its largest diameter in the right ovary (Panel D, asterisk). A gastric biopsy showed mucin-rich signet-ring-cell adenocarcinoma, confirming a diagnosis of gastric adenocarcinoma with ovarian metastasis (also known as a Krukenberg tumor). The cancer initially responded to systemic therapy but had progressed by the 6-month follow-up. Huei-Jing Wang, M.D., Ph.D., and S. Chu-Sung Hu, M.B., B.S., M.Phil.March 16, 2023 N Engl J Med 2023; 388:1031 DOI: 10.1056/NEJMicm2207017

Оставить комментарий

Популярные посты:

figunet

Обзор модельного ряда Belgee: характеристики X70, X50 и S50

lsn24

Комиссию за переводы денежных средств между членами семьи отменят

znat_kak

РЖД демонстративно не отвечает на вопрос «Чей Крым?» Стесняется, наверное

lemming809

Без названия

elmaspb

Московская соборная мечеть

colonelcassad

Отчистились от неискренних людей

svetlyachok_vtk

Какое блаженство, что блещут снега...

tamarajer

Есть надежда!

avk-tehnik

Жаркое лето 1941-го

• Ранее
• Архив