Доксициклин и солнце

dok_zlo — 27.09.2025

A 15-year-old girl with a history of acne vulgaris presented to the dermatology clinic with a 2-week history of a progressively worsening painful, blistering rash on both hands. One week before the onset of the rash, she had started taking oral doxycycline for treatment of her acne. She routinely played outdoors on park swings without sun protection. On physical examination, erythematous plaques with scattered vesicles were noted across the backs of her fingers, most prominently on the dorsal aspect of the thumbs and dorsolateral side of the index fingers. A diagnosis of doxycycline-induced phototoxicity was made. Doxycycline-induced phototoxicity is a dose-dependent reaction involving sun-exposed areas of the skin. Owing to the fact that the dorsal thumbs and dorsolateral index fingers are directly exposed to the sun regardless of specific outdoor activity, the development of a rash on those areas may be a helpful physical examination finding in identifying phototoxic drug reactions. Doxycycline was discontinued, and treatment with topical clobetasol was given. In the days after presentation, the rash resolved.
Grace Boyd, B.S., and Carol Cheng, M.D.Author Info & Affiliations
Published September 24, 2025
N Engl J Med 2025;393: e19
DOI: 10.1056/NEJMicm2506434
VOL. 393 NO. 12

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